Rad and Rad-related GTPases Interact with Calmodulin and Calmodulin-dependent Protein Kinase II
نویسندگان
چکیده
منابع مشابه
Calcium/calmodulin-dependent protein kinase II.
There is a great deal known about the in vitro properties of CaM kinase II, both in terms of its substrate specificity and its regulation by calmodulin and autophosphorylation. Much of this characterization is based on experiments performed with the rat brain isozyme of CaM kinase II, although in the aspects examined to date isozymes of the kinase from other tissues appear to behave in a broadl...
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Ca2#/calmodulin-dependent protein kinase II (CaMKII) isozyme variability is the result of alternative usage of variable domain sequences. Isozyme expression is cell type-specific to transduce the appropriate Ca2# signals. We have determined the subcellular targeting domain of "E CaMK-II, an isozyme that induces neurite outgrowth, and of a structurally similar isozyme, !C CaMK-II, which does not...
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The search for “memory molecules” and why CaMKII is an appealing candidate Since the time neuroscientists first recognized that biochemical events inside neurons could influence the function of the brain, there have been people looking for “memory molecules.” This elusive ion, small molecule, protein, or nucleic acid would be the keystone on which memory was built; understanding the memory mole...
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Understanding relationships between heart failure and arrhythmias, important causes of suffering and sudden death, remains an unmet goal for biomedical researchers and physicians. Evidence assembled over the past decade supports a view that activation of the multifunctional Ca(2+) and calmodulin-dependent protein kinase II (CaMKII) favors myocardial dysfunction and cell membrane electrical inst...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.18.11832